Influenza vaccination in HBsAg positive chronic active hepatitis patients treated with interferon
Identifieur interne : 002848 ( Main/Exploration ); précédent : 002847; suivant : 002849Influenza vaccination in HBsAg positive chronic active hepatitis patients treated with interferon
Auteurs : R. A. Heijtink [Pays-Bas] ; N. Masurel [Pays-Bas] ; W. Weimar [Pays-Bas] ; S. W. Schalm [Pays-Bas]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1980-12-01.
English descriptors
- Teeft :
- Antibody response, Antibody titer, Antibody titers, Antigenic relationship, Chronic hepatitis, Equine, Equine influenza, Equine virus, Erasmus university rotterdam, Hbsag, Heijtink, Hemagglutination inhibition tests, Hepatitis, Hepatitis patients, Heqlneql, Heqlneql strain, Heqlneql virus, Heterologous elevations, Hswln1, Hswln1 antibodies, Immune, Immune response, Influenza, Influenza antibodies, Influenza strains, Influenza vaccination, Influenza virus, Interferon, Interferon treatment, Leucocyte interferon, Masurel, Mulder, Other influenza, Other influenza strains, Placebo, Placebo group, Placebo groups, Prevaccination, Prevaccination sera, Prevaccination titers, Significant difference, Significant differences, Strains hswln1, Swine influenza virus, Titer, Untreated patients, Vaccination, Vaccine virus, Winter season.
Abstract
Abstract: Sixteen patients with hepatitis B antigen (HBsAg) positive chronic active hepatitis (CAH) were vaccinated with the nonhuman influenza A virus Heq1Neq1; eight patients were also treated with leucocyte interferon. Prevaccination sera were negative for specific antibody in hemagglutination inhibition tests. Four weeks after vaccination all patients had responded with a homologous antibody titer. Between the interferon-treated and the untreated groups the differences in antibody titers against the vaccine virus were not significant. Concomitant with the antibody response against the nonhuman influenza virus, a fourfold or higher antibody rise was observed against the influenza A virus strains Hsw1N1 (in six treated and seven untreated patients), H1N1 (in six treated and four untreated patients) and H3N2 (in five treated patients only). The results suggest that a normal specific antibody response in HBsAg positive chronic active hepatitis patients is not significantly altered by leucocyte interferon, and that non-specific antibody production can occur in the absence of a serologic relationship.
Url:
DOI: 10.1007/BF02123710
Affiliations:
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A." last="Heijtink">R. A. Heijtink</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam</wicri:regionArea><wicri:noRegion>DR Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Masurel, N" sort="Masurel, N" uniqKey="Masurel N" first="N." last="Masurel">N. Masurel</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000, DR Rotterdam</wicri:regionArea><wicri:noRegion>DR Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Weimar, W" sort="Weimar, W" uniqKey="Weimar W" first="W." last="Weimar">W. 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Schalm</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus University Rotterdam</wicri:regionArea><wicri:noRegion>Erasmus University Rotterdam</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="ISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1980-12-01">1980-12-01</date><biblScope unit="volume">169</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="31">31</biblScope><biblScope unit="page" to="38">38</biblScope></imprint><idno type="ISSN">0300-8584</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8584</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody response</term><term>Antibody titer</term><term>Antibody titers</term><term>Antigenic relationship</term><term>Chronic hepatitis</term><term>Equine</term><term>Equine influenza</term><term>Equine virus</term><term>Erasmus university rotterdam</term><term>Hbsag</term><term>Heijtink</term><term>Hemagglutination inhibition tests</term><term>Hepatitis</term><term>Hepatitis patients</term><term>Heqlneql</term><term>Heqlneql strain</term><term>Heqlneql virus</term><term>Heterologous elevations</term><term>Hswln1</term><term>Hswln1 antibodies</term><term>Immune</term><term>Immune response</term><term>Influenza</term><term>Influenza antibodies</term><term>Influenza strains</term><term>Influenza vaccination</term><term>Influenza virus</term><term>Interferon</term><term>Interferon treatment</term><term>Leucocyte interferon</term><term>Masurel</term><term>Mulder</term><term>Other influenza</term><term>Other influenza strains</term><term>Placebo</term><term>Placebo group</term><term>Placebo groups</term><term>Prevaccination</term><term>Prevaccination sera</term><term>Prevaccination titers</term><term>Significant difference</term><term>Significant differences</term><term>Strains hswln1</term><term>Swine influenza virus</term><term>Titer</term><term>Untreated patients</term><term>Vaccination</term><term>Vaccine virus</term><term>Winter season</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Sixteen patients with hepatitis B antigen (HBsAg) positive chronic active hepatitis (CAH) were vaccinated with the nonhuman influenza A virus Heq1Neq1; eight patients were also treated with leucocyte interferon. Prevaccination sera were negative for specific antibody in hemagglutination inhibition tests. Four weeks after vaccination all patients had responded with a homologous antibody titer. Between the interferon-treated and the untreated groups the differences in antibody titers against the vaccine virus were not significant. Concomitant with the antibody response against the nonhuman influenza virus, a fourfold or higher antibody rise was observed against the influenza A virus strains Hsw1N1 (in six treated and seven untreated patients), H1N1 (in six treated and four untreated patients) and H3N2 (in five treated patients only). The results suggest that a normal specific antibody response in HBsAg positive chronic active hepatitis patients is not significantly altered by leucocyte interferon, and that non-specific antibody production can occur in the absence of a serologic relationship.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Heijtink, R A" sort="Heijtink, R A" uniqKey="Heijtink R" first="R. A." last="Heijtink">R. A. Heijtink</name></noRegion><name sortKey="Masurel, N" sort="Masurel, N" uniqKey="Masurel N" first="N." last="Masurel">N. Masurel</name><name sortKey="Schalm, S W" sort="Schalm, S W" uniqKey="Schalm S" first="S. W." last="Schalm">S. W. Schalm</name><name sortKey="Weimar, W" sort="Weimar, W" uniqKey="Weimar W" first="W." last="Weimar">W. Weimar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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